- Salvage Yards, Port Colborne - Auto, Motorcycle, Boat, Trucks, etc
- Sandwich Shop Restaurants, Port Colborne
- Satellite Communication Downlinking & Uplinking, Port Colborne
- Scrap & Waste Machinery, Port Colborne
- Scrap & Waste Materials, Port Colborne
- Screening & Preventative Health Services, Port Colborne
- Seafood Restaurants, Port Colborne
- Secondary Schools, Port Colborne
- Security Alarm Systems - Home & Business, Port Colborne
- Security Brokers & Dealers, Port Colborne
- Security Control Systems & Monitoring, Port Colborne - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Guard & Patrol Service, Port Colborne - Bodyguard, Guard Dogs, Etc
- Security Investigative Services, Port Colborne
- Security Services, Port Colborne
- Senior Citizens Housing, Port Colborne
- Senior Citizens Service & Health Organizations, Port Colborne
- Septic Systems Installation & Repair, Port Colborne
- Septic Tank Pumping & Cleaning, Port Colborne - Septic Systems
- Septic Tanks & Septic Systems Contractors, Port Colborne - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Sheet Metal Contractors, Port Colborne - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Port Colborne
- Ship & Boat Building & Repairing, Port Colborne
- Shoe Stores, Port Colborne - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Port Colborne
- Siding Contractors, Port Colborne - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Siding Materials, Port Colborne
- Signs, Port Colborne
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- Skating Rink & Hockey Operation Services, Port Colborne
- Skin Care & Cosmetology Salons, Port Colborne
- Skin Care Products & Treatments, Port Colborne
- Snacks & Desserts, Port Colborne
- Snow Removal Services, Port Colborne - Snow Plow Service
- Social Clubs & Organizations, Port Colborne
- Social Services & Welfare, Port Colborne
- Societies & Foundation Associations, Port Colborne
- Space Planning, Port Colborne
- Special Coatings, Port Colborne - Protective Coatings
- Special Dies Tools Jigs & Fixtures Manufacturers, Port Colborne
- Special Events Photographers, Port Colborne
- Special Interest Schools Or Instruction, Port Colborne
- Speciality Food Stores, Port Colborne
- Specialty Animal Services, Port Colborne
- Specialty Goods Storage, Port Colborne
- Specialty Stores, Port Colborne
- Speech & Hearing Specialists, Port Colborne
- Sporting Goods Stores, Port Colborne
- Sports & Recreational Services, Port Colborne
- Staffing & Support Services, Port Colborne
- Steel Manufacturers, Port Colborne
- Stone, Port Colborne
- Stoves & Furnace Equipment, Port Colborne - Fittings & Repair Parts
- Submarine Sandwich Restaurants, Port Colborne
- Surveyor Services, Port Colborne - Surveying Service
- Sweepers & Scrubbers Industrial, Port Colborne - Sweeping Service
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